Thermo Fisher Scientific SOCS1 Polyclonal Antibody
SOCS1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. 세포 내 사이토카인 신호 조절 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 149–211 of SOCS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544715 |
Product Specific Information
- Recommended positive controls: HepG2, mouse brain, HOK, DOK
- Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Suppressor of Cytokine Signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate immune cell responses to cytokines.
SOCS1 suppresses dendritic cell and T-cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, which is required for cytokine receptor signaling.
Additionally, SOCS1 has E3 ubiquitin ligase activity, mediating the degradation of target proteins via the proteasome.
Through this mechanism, SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating degradation of the adaptor protein TIRAP.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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