Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI3A12), TrueMAB

Applications

• Western Blot (WB): 1:500 dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Ubiquitin-mediated proteolysis involves transferring ubiquitin (Ub) to lysine residues on target proteins, marking them for degradation by the 26S proteasome.
The UFD1L protein plays a role in the Ub-fusion degradation (UFD) pathway, regulating the stability of Ub-conjugated proteins.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, implying a link between UFD1L function and developmental processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.