Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI3A12), TrueMAB
UFD1L 단백질을 표적으로 하는 Mouse IgG3 단일클론 항체로, Western blot에 최적화됨. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능. 인간 UFD1L 단백질을 항원으로 제작된 연구용 항체.
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A12 |
| Immunogen | Full-length human recombinant UFD1L protein produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Ubiquitin-mediated proteolysis involves transferring ubiquitin (Ub) to lysine residues on target proteins, marking them for degradation by the 26S proteasome.
The UFD1L protein plays a role in the Ub-fusion degradation (UFD) pathway, regulating the stability of Ub-conjugated proteins.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, implying a link between UFD1L function and developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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