Thermo Fisher Scientific IL15 Monoclonal Antibody (2F6)
인간 IL-15에 특이적인 Mouse IgG2b 단클론 항체로, WB, IHC, ELISA에 적합. IL-15 관련 면역반응 연구 및 사이토카인 신호전달 분석에 활용 가능. PBS 기반 액상 형태로 보존제 없음, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1.5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F6 |
| Immunogen | IL15 (NP_000576, 49–162 a.a) full length recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH DTVENLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS
Target Information
IL-15 (Interleukin 15) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both bind common hematopoietin receptor subunits and may compete for the same receptor, thereby negatively regulating each other’s activity.
IL-15 induces activation of JAK kinases and transcription activators STAT3, STAT5, and STAT6. In mouse studies, IL-15 may increase expression of apoptosis inhibitor Bcl-xL through STAT6 activity, preventing apoptosis.
IL-15 plays a crucial role in the growth and differentiation of T and B lymphocytes, NK cells, macrophages, and monocytes, and is involved in immune responses, allograft rejection, and autoimmune disease pathogenesis.
It is also a pro-inflammatory cytokine implicated in disorders such as rheumatoid arthritis, psoriasis, and pulmonary inflammation. IL-15 neutralization shows potential therapeutic benefits in models of psoriasis and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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