Thermo Fisher Scientific PXR Monoclonal Antibody (1D12G1)
PXR 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, ICC/IF, Flow cytometry, ELISA에 사용 가능. 인간 시료에 반응하며 Protein G로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D12G1 |
| Immunogen | Purified recombinant fragment of human NR1I2 (AA: 1–142) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787431 |
Product Specific Information
MA5-31808 has been tested in indirect ELISA.
Target Information
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by compounds that induce CYP3A4, such as dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms have been described for this gene, some using non-AUG translation initiation codons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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