Thermo Fisher Scientific Human NOD1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human NOD1.
PEP-1129 can be used as a blocking peptide with polyclonal antibody PA5-21015.

Target Information

NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins involved in innate immune defense.
NOD1 contains:

• An N-terminal caspase recruitment domain (CARD)
• A centrally located nucleotide-binding domain (NBD)
• Ten tandem leucine-rich repeats (LRRs) in its C-terminus

The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B.
LRRs participate in protein-protein interactions, and mutations in the NBD may affect oligomerization and subsequent LRR domain function.
This protein acts as an intracellular pattern-recognition receptor (PRR) initiating inflammation in response to certain bacteria via detection of bacterial diaminopimelic acid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.