Thermo Fisher Scientific NOX4 Recombinant Rabbit Monoclonal Antibody (2B2K7)
NOX4 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, ELISA에 적합합니다. HEK293 세포에서 발현된 재조합 항체이며, 고순도의 Affinity chromatography 정제 제품입니다. 인간, 생쥐, 랫트 시료에 반응하며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2B2K7 |
| Immunogen | Synthetic peptide corresponding to amino acids 479–578 of human NADPH oxidase 4 (NOX4) (NP_058627.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094260 |
Product Specific Information
Immunogen sequence:
LHNKFWQENR PDYVNIQLYL SQTDGIQKII GEKYHALNSR LFIGRPRWKL LFDEIAKYNR GKTVGVFCCG PNSLSKTLHK LSNQNNSYGT RFEYNKESFS
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.
NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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