Thermo Fisher Scientific NOX4 Recombinant Rabbit Monoclonal Antibody (2B2K7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10,000-1:20,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2B2K7

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 479-578 of human NADPH oxidase 4 (NOX4) (NP_058627.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NOX4,uniProtId:Q9NPH5-1,ncbiNodeId:9606,antigenRange:479-578,antigenLength:578,antigenImageFileName:MA5-51408_NOX4_Q9NPH5-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51408_NOX4_Q9NPH5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3094260

Product Specific Information

Immunogen sequence: LHNKFWQENR PDYVNIQLYL SQTDGIQKII GEKYHALNSR LFIGRPRWKL LFDEIAKYNR GKTVGVFCCG PNSLSKTLHK LSNQNNSYGT RFEYNKESFS

Target Information

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.