Thermo Fisher Scientific LPIN3 Monoclonal Antibody (OTI2B7), TrueMAB
인간 LPIN3 단백질을 인식하는 Mouse IgG2b 단클론 항체로 Western blot에 적합. 무보존제, 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도 유지. 연구용으로 지방대사 및 리피노디스트로피 관련 단백질 분석에 활용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B7 |
| Immunogen | Full length human recombinant LPIN3 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Human lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mutations in the mouse fatty liver dystrophy gene produce similar phenotypes. The Lpin1 gene was identified as responsible for fatty liver dystrophy, encoding the nuclear protein lipin.
Lipin is highly expressed in adipose tissue and induced during preadipocyte differentiation, indicating its role in normal adipose tissue development and as a candidate gene for human lipodystrophy.
Human LPIN1 maps to chromosome 2p25, LPIN2 to 18p11, and LPIN3 to 20q11–q12. Mouse homologs Lpin1, Lpin2, and Lpin3 map to chromosomes 12, 17, and 2, respectively.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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