Thermo Fisher Scientific CDKN2A Monoclonal Antibody (OTI1E7), TrueMAB
CDKN2A 단백질을 인식하는 고특이성 Monoclonal Antibody로, Human 시료에 반응합니다. Western blot에 최적화되어 있으며, Lyophilized 형태로 제공됩니다. 연구용으로 CDK4/p53 경로 관련 세포주기 조절 연구에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E7 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The CDKN2A gene produces multiple transcript variants with distinct first exons.
Two variants encode CDK4 kinase inhibitors, while another variant (ARF transcript) encodes a structurally unrelated protein that stabilizes tumor suppressor p53 by binding and sequestering MDM2.
Despite structural differences, all isoforms contribute to cell cycle G1 control.
This gene is frequently mutated or deleted in various tumors and functions as an important tumor suppressor gene.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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