Thermo Fisher Scientific PCK1 Polyclonal Antibody, MaxPab
Thermo Fisher Scientific의 PCK1 Polyclonal Antibody는 인간 PCK1 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot에 최적화되어 있으며, Affinity chromatography로 정제된 액상 형태입니다. Gluconeogenesis 관련 연구에 적합하며, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): Tested Dilution 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full-length human PCK1 protein (NP_002582.2, 1–622 a.a) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MPPQLQNGLN LSAKVVQGSL DSLPQAVREF LENNAELCQP DHIHICDGSE EENGRLLGQM EEEGILRRLK KYDNCWLALT DPRDVARIES KTVIVTQEQR DTVPIPKTGL SQLGRWMSEE DFEKAFNARF PGCMKGRTMY VIPFSMGPLG SPLSKIGIEL TDSPYVVASM RIMTRMGTPV LEALGDGEFV KCLHSVGCPL PLQKPLVNNW PCNPELTLIA HLPDRREIIS FGSGYGGNSL LGKKCFALRM ASRLAKEEGW LAEHMLVLGI TNPEGEKKYL AAAFPSACGK TNLAMMNPSL PGWKVECVGD DIAWMKFDAQ GHLRAINPEN GFFGVAPGTS VKTNPNAIKT IQKNTIFTNV AETSDGGVYW EGIDEPLASG VTITSWKNKE WSSEDGEPCA HPNSRFCTPA SQCPIIDAAW ESPEGVPIEG IIFGGRRPAG VPLVYEALSW QHGVFVGAAM RSEATAAAEH KGKIIMHDPF AMRPFFGYNF GKYLAHWLSM AQHPAAKLPK IFHVNWFRKD KEGKFLWPGF GENSRVLEWM FNRIDGKAST KLTPIGYIPK EDALNLKGLG HINMMELFSI SKEFWEKEVE DIEKYLEDQV NADLPCEIER EILALKQRIS QM
Target Information
Phosphoenolpyruvate Carboxykinase 1 (PCK1) is a main control point for the regulation of gluconeogenesis. During gluconeogenesis, PCK1 acts as the rate-limiting enzyme. It regulates the formation and maintenance of memory CH8(+) T-cells via gluconeogenesis and controls levels of metabolic intermediates in the citric acid cycle through cataplerosis and anaplerosis.
When glucose levels are high, PCK1 catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP). When levels are low, it catalyzes the anaplerotic conversion of PEP to oxaloacetate. Phosphorylation at Ser-90 by AKT1 enables PCK1 to act as a protein kinase, promoting lipogenesis by disrupting INSIG–SCAP interactions and enhancing SREBP nuclear translocation and lipogenesis-related gene transcription.
An important paralog of this gene is PCK2.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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