Thermo Fisher Scientific PCK1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): Tested Dilution 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MPPQLQNGLN LSAKVVQGSL DSLPQAVREF LENNAELCQP DHIHICDGSE EENGRLLGQM EEEGILRRLK KYDNCWLALT DPRDVARIES KTVIVTQEQR DTVPIPKTGL SQLGRWMSEE DFEKAFNARF PGCMKGRTMY VIPFSMGPLG SPLSKIGIEL TDSPYVVASM RIMTRMGTPV LEALGDGEFV KCLHSVGCPL PLQKPLVNNW PCNPELTLIA HLPDRREIIS FGSGYGGNSL LGKKCFALRM ASRLAKEEGW LAEHMLVLGI TNPEGEKKYL AAAFPSACGK TNLAMMNPSL PGWKVECVGD DIAWMKFDAQ GHLRAINPEN GFFGVAPGTS VKTNPNAIKT IQKNTIFTNV AETSDGGVYW EGIDEPLASG VTITSWKNKE WSSEDGEPCA HPNSRFCTPA SQCPIIDAAW ESPEGVPIEG IIFGGRRPAG VPLVYEALSW QHGVFVGAAM RSEATAAAEH KGKIIMHDPF AMRPFFGYNF GKYLAHWLSM AQHPAAKLPK IFHVNWFRKD KEGKFLWPGF GENSRVLEWM FNRIDGKAST KLTPIGYIPK EDALNLKGLG HINMMELFSI SKEFWEKEVE DIEKYLEDQV NADLPCEIER EILALKQRIS QM

Target Information

Phosphoenolpyruvate Carboxykinase 1 (PCK1) is a main control point for the regulation of gluconeogenesis. During gluconeogenesis, PCK1 acts as the rate-limiting enzyme. It regulates the formation and maintenance of memory CH8(+) T-cells via gluconeogenesis and controls levels of metabolic intermediates in the citric acid cycle through cataplerosis and anaplerosis.

When glucose levels are high, PCK1 catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP). When levels are low, it catalyzes the anaplerotic conversion of PEP to oxaloacetate. Phosphorylation at Ser-90 by AKT1 enables PCK1 to act as a protein kinase, promoting lipogenesis by disrupting INSIG–SCAP interactions and enhancing SREBP nuclear translocation and lipogenesis-related gene transcription.
An important paralog of this gene is PCK2.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.

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