Thermo Fisher Scientific SETD8 Recombinant Rabbit Monoclonal Antibody (JM73-43)
SETD8 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공. Western blot 및 Flow cytometry에 적합. 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션. 연구용으로만 사용 가능.
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Thermo Fisher Scientific SETD8 Recombinant Rabbit Monoclonal Antibody (JM73-43)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM73-43 |
| Immunogen | Synthetic peptide within Human KMT5A aa 51–100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810035 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4. This monomethylation is enriched during mitosis and represents a specific epigenetic repression marker.
SETD8 functions primarily in euchromatin regions, playing a central role in silencing euchromatic genes. It is essential for cell proliferation and contributes to maintaining DNA structure during mitosis, chromosome condensation, and cytokinesis. Nucleosomes are preferred substrates compared to free histones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 정보: MA5-32758_SETD8_Q9NQR1-1_Rabbit.svg, MA5-32758_SETD8_Q9NQR1-1_Rabbit_PDP.jpeg)
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