Thermo Fisher Scientific PYCARD Polyclonal Antibody
인간 PYCARD 단백질을 인식하는 Rabbit Polyclonal Antibody로, apoptosis 및 염증 관련 연구에 적합. WB, IHC(F), ICC/IF 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 장기 보관 시 -20°C 권장.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–195 of Human TMS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545191 |
Product Specific Information
- Recommended positive controls: THP-1, 3xFlag-human TMS1-transfected 293T
- Predicted reactivity: Rhesus Monkey (91%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Functions as a key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promoting caspase-8-dependent proteolytic maturation of BID independently of FADD and mediating mitochondrial translocation of BAX. Plays a role in macrophage pyroptosis, a caspase-1-dependent inflammatory cell death, and acts as an integral adapter in inflammasome assembly, leading to activation of caspase-1 and secretion of proinflammatory cytokines. Participates in innate and adaptive immune responses, dendritic cell maturation, cytokine transcriptional activation, and NF-kappa-B pathway modulation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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