Thermo Fisher Scientific CD86 Recombinant Rabbit Monoclonal Antibody (103)
Human CD86/B7-2 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 높은 특이성과 일관성을 제공합니다. ICC/IF 및 ELISA에 적합하며, 보존제가 없는 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1:20–1:100 | View 1 publication |
| ELISA | 1:250–1:2,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 103 |
| Immunogen | Recombinant Human CD86/B7-2 Protein (Met1–His239) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785960 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin–free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Human CD86/B7-2.
Target Information
CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Insufficient co-stimulation involving CD86/CD80 can induce immune tolerance.
CD86 is a type I membrane protein and a member of the immunoglobulin superfamily. It is expressed by antigen-presenting cells and binds to CD28 and CTLA4 on T cells.
- Binding with CD28: Provides costimulatory signal for T-cell activation
- Binding with CTLA4: Negatively regulates T-cell activation and diminishes immune response
Alternative splicing results in multiple transcript variants encoding different isoforms. CD86 dysfunction has been associated with diseases such as gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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