Thermo Fisher Scientific TRAF6 Polyclonal Antibody
TRAF6 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고농도(500 µg/mL) 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein TNF Receptor Associated Factor 6 (amino acids 153–423 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903966 |
Target Information
Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress.
TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing activation of different signal cascades depending on the TRAFs involved.
For example:
- TRAF2 and TRAF3 directly bind to CD40, a NF receptor superfamily member involved in B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes.
- TRAF2 along with TRAF6 is required for CD40 signaling in nonhemopoietic cells.
- TRAF2 also interacts with lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and apoptosis inhibitors cIAP1 and Smac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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