Thermo Fisher Scientific PKC alpha Recombinant Rabbit Monoclonal Antibody (SU31-08)
PKC alpha 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot, IHC, ICC, Flow cytometry, IP 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, 로트 간 일관성이 우수합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA532106
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
| Immunoprecipitation (IP) | 1:10–1:50 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SU31-08 |
| Immunogen | Recombinant protein within Human PKC alpha aa 560–672 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809399 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the extensive rabbit immune repertoire
Target Information
The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated by intracellular signaling pathways. In humans, at least 12 PKC isoforms have been identified, differing in structure, localization, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family, which are Ca²⁺- and phospholipid-dependent. PKC family members phosphorylate various protein targets and participate in diverse signaling pathways.
They act as receptors for phorbol esters, a class of tumor promoters. PKC alpha is involved in processes such as cell adhesion, transformation, cell cycle checkpoint control, and cell volume regulation.
Mouse knockout studies indicate its role in cardiac contractility and Ca²⁺ handling in myocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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