Thermo Fisher Scientific Nurr1 Polyclonal Antibody
인간 Nurr1/NR4A2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 1 mg/mL 농도의 액상형 시약이며 PBS+50% glycerol buffer에 보관됩니다. 도파민성 신경계 연구 및 파킨슨병 관련 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NR4A2 (Accession P43354), corresponding to amino acid residues M1–D45 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900316 |
Product Specific Information
Antibody detects endogenous levels of total Nurr1/NR4A2.
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans.
NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression.
Misregulation of this gene may be associated with rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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