Thermo Fisher Scientific RIP1 Monoclonal Antibody (3B5B6)
인간 RIP1 단백질을 인식하는 mouse monoclonal antibody로 Western blot, Flow cytometry, ELISA에 적합합니다. 고순도 Protein G 정제, 1 mg/mL 농도로 제공되며, PBS와 sodium azide 함유. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:200–1:400
ELISA
- Tested Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B5B6 |
| Immunogen | Purified recombinant fragment of human RIPK1 (AA: 131–277) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090928 |
Target Information
RIP1 (Receptor-interacting serine/threonine-protein kinase 1) is a kinase that transduces inflammatory and cell-death signals following activation of death receptors, PRRs, or DNA damage. Upon TNFR1 activation by TNF-alpha cytokines, TRADD and TRAF2 are recruited, leading to phosphorylation of DAB2IP at Ser-728 and activation of the MAP3K5-JNK apoptotic cascade. Ubiquitination via Lys-63-linked chains by TRAF2 enhances signaling through MAPK and NF-κB pathways, promoting inflammatory gene activation. Polyubiquitinated RIP1 binds to IKBKG/NEMO, critical for NF-κB activation. RIPK1-RIPK3 complexes induce programmed necrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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