Thermo Fisher Scientific IL-15 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize both reported isoforms (NP_000576.1; NP_751915.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

IL-15 (Interleukin 15) is a cytokine that regulates T and natural killer (NK) cell activation and proliferation.
IL-15 and IL-2 share many biological activities, binding common hematopoietin receptor subunits and potentially competing for the same receptor, thereby regulating each other’s activity.

IL-15 induces activation of JAK kinases and phosphorylation of STAT3, STAT5, and STAT6 transcription activators. In mouse studies, IL-15 may increase expression of the apoptosis inhibitor Bcl-xL, preventing apoptosis.

It plays a key role in the growth and differentiation of T and B lymphocytes, NK cells, macrophages, and monocytes, and is involved in immune responses, allograft rejection, and autoimmune disease pathogenesis.
IL-15 is a pro-inflammatory cytokine implicated in disorders such as rheumatoid arthritis, psoriasis, and pulmonary inflammation. Neutralization of IL-15 has shown beneficial effects in models of psoriasis and diabetes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.