Thermo Fisher Scientific IL-15 Polyclonal Antibody
IL-15 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot에 적합합니다. 인간 시료에 반응하며, T 및 NK 세포 활성 조절 연구에 유용합니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- PA5142964
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DATLYTESDVHPS (aa 70–82) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933604 |
Product Specific Information
- This antibody is expected to recognize both reported isoforms (NP_000576.1; NP_751915.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
IL-15 (Interleukin 15) is a cytokine that regulates T and natural killer (NK) cell activation and proliferation.
IL-15 and IL-2 share many biological activities, binding common hematopoietin receptor subunits and potentially competing for the same receptor, thereby regulating each other’s activity.
IL-15 induces activation of JAK kinases and phosphorylation of STAT3, STAT5, and STAT6 transcription activators. In mouse studies, IL-15 may increase expression of the apoptosis inhibitor Bcl-xL, preventing apoptosis.
It plays a key role in the growth and differentiation of T and B lymphocytes, NK cells, macrophages, and monocytes, and is involved in immune responses, allograft rejection, and autoimmune disease pathogenesis.
IL-15 is a pro-inflammatory cytokine implicated in disorders such as rheumatoid arthritis, psoriasis, and pulmonary inflammation. Neutralization of IL-15 has shown beneficial effects in models of psoriasis and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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