Thermo Fisher Scientific Nodal Polyclonal Antibody
Nodal 단백질을 인식하는 Thermo Fisher의 goat polyclonal antibody로, WB 및 IHC(P)에서 검증됨. 인간 및 랫트 시료에 반응하며, 0.5 mg/mL 농도의 액상 형태. TBS(pH 7.3) 버퍼에 0.5% BSA 포함, -20°C에서 보관. 암세포 분화 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence DRSQLCRKVKFQ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932951 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
NODAL is an important TGF-beta family protein involved in cellular differentiation. It is constitutively expressed in many developing tissues but is also associated with the differentiation and progression of various cancers. NODAL expression is regulated by the Notch signaling pathway, and its dysregulation contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine cancer stage and metastatic progression when tested in IHC. NODAL interactions with Cripto also promote tumor progression. Overexpression of NODAL has been linked to preeclamptic placenta.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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