Thermo Fisher Scientific SCN11A Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
PLKKLYEPIV TTTKRKEEER GAAIIQKAFR KYMMKVTKGD QGDQNDLENG PHSPLQTLCN GDLSSFGVAK GKVHCD

Highest antigen sequence identity to the following orthologs:

• Mouse: 59%
• Rat: 61%

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
These channels possess two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of the ENaC protein (alpha, beta, and gamma). ENaC plays an essential role in trans-epithelial sodium and fluid balance in kidney, lung, and colon.
It mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure.
ENaC is regulated partly through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel.
Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddell’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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