Thermo Fisher Scientific HSP701L Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total HSPA1L.

Target Information

In response to adverse environmental changes, cells from many organisms increase the expression of heat shock proteins (HSPs). One class, the small heat shock proteins, includes diverse proteins ranging from approximately 15 to >30 kDa. A single form is found in yeast and human cells, while multiple related forms exist in higher plants.

Elevated expression of certain stress proteins has been linked to neoplasia, as observed in estrogen-induced proteins in breast cancer cells. Hsp27, for instance, shows rapid phosphorylation increases in response to mitogens, tumor promoters (e.g., phorbol esters), and calcium ionophores. The 24 kDa estrogen-induced protein correlates with steroid hormone receptor expression and is highly expressed in breast carcinoma. Studies also suggest that Hsp27 levels correlate with endometrial adenocarcinomas. Regulation of human Hsp27 by estrogens and heat shock is reminiscent of ecdysteroid and heat shock activation of drosophila Hsp20 genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.