Thermo Fisher Scientific HSP701L Polyclonal Antibody
HSP701L 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity chromatography로 정제된 1 mg/mL 액상 제품입니다. PBS/glycerol buffer에 보관하며 -20°C에서 안정적입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HSPA1L (Accession P34931), corresponding to amino acid residues D227–S277. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854563 |
Product Specific Information
This antibody detects endogenous levels of total HSPA1L.
Target Information
In response to adverse environmental changes, cells from many organisms increase the expression of heat shock proteins (HSPs). One class, the small heat shock proteins, includes diverse proteins ranging from approximately 15 to >30 kDa. A single form is found in yeast and human cells, while multiple related forms exist in higher plants.
Elevated expression of certain stress proteins has been linked to neoplasia, as observed in estrogen-induced proteins in breast cancer cells. Hsp27, for instance, shows rapid phosphorylation increases in response to mitogens, tumor promoters (e.g., phorbol esters), and calcium ionophores. The 24 kDa estrogen-induced protein correlates with steroid hormone receptor expression and is highly expressed in breast carcinoma. Studies also suggest that Hsp27 levels correlate with endometrial adenocarcinomas. Regulation of human Hsp27 by estrogens and heat shock is reminiscent of ecdysteroid and heat shock activation of drosophila Hsp20 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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