Thermo Fisher Scientific Human MAVS Synthetic Peptide

Thermo Fisher Scientific Human MAVS Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the carboxy terminus of human VISA.
PEP-0468 can be used as a blocking peptide with polyclonal antibody PA5-20348.

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger the immune response.
MAVS is a mitochondrial membrane protein identified as a critical component in the IFN-beta signaling pathway that recruits IRF-3 to RIG-I, leading to activation of NF-kappa-B.
MAVS interacts with other components of the innate immune pathway such as TLR adapter protein TRIF, TRAF2, and TRAF6. It also interacts with IKK-alpha, IKK-beta, and IKK-iota kinases through its C-terminal region. Cleavage of this region by Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. Multiple isoforms of MAVS are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.