Thermo Fisher Scientific Furin Recombinant Rabbit Monoclonal Antibody (JB35-53)
Furin 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot과 IHC(P)에서 검증됨. 고순도 Protein A 정제, 1 mg/mL 농도. TBS buffer(40% glycerol 포함) 보존, -20°C에서 보관. 다양한 인체 및 조직 샘플에서 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JB35-53 |
| Immunogen | Recombinant protein within Human Furin (aa 261–310) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848585 |
Product Specific Information
Positive Control:
HepG2, HeLa, MCF-7, human liver tissue, human colon tissue, human placenta tissue, mouse brain tissue.
Target Information
Furin is a membrane-associated, calcium-dependent serine protease belonging to the subtilisin-like prohormone convertase (PC) family. Members of this family cleave most prohormones and neuropeptide precursors, as well as various viral and bacterial proteins.
Furin and related PCs share structural features including:
- ~10 kDa amino-terminal proregion
- ~55 kDa conserved catalytic domain
- Variable-length carboxyl-terminal domain
Furin becomes active after proregion cleavage and is unique among PCs for having a transmembrane domain. It cleaves substrates at the carboxyl-terminus of the consensus sequence RX(K/R)R.
The peptide sequence C771PSDSEEDEG780 localizes furin to the trans-Golgi network, and phosphorylation within this region regulates its intracellular routing. The Y759KGL762 sequence mediates internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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