ELK Biotechnology TRIP15 rabbit pAb
TRIP15(COPS2) 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 유래 합성 펩타이드(AA 181-230)를 면역원으로 제작되었으며, 세포질 및 핵에 발현하는 단백질 검출에 사용됩니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology TRIP15 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TRIP15 rabbit pAb |
| Alternative Names | COPS2; CSN2; TRIP15; COP9 signalosome complex subunit 2; SGN2; Signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human COPS2 (AA range: 181–230) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kDa |
| Gene ID (Human) | 9318 |
| Human Swiss-Prot No. | P61201 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat, Monkey |
Background
Essential component of the COP9 signalosome complex (CSN), which regulates multiple cellular and developmental processes. The CSN complex controls the ubiquitin conjugation pathway by mediating deneddylation of cullin subunits in SCF-type E3 ligase complexes, thereby reducing their ubiquitin ligase activity. It is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, and IRF8/ICSBP through association with CK2 and PKD kinases.
CSN-dependent phosphorylation of TP53 and JUN promotes or protects degradation by the ubiquitin system, respectively. COPS2 plays a role in early neuronal differentiation via interaction with NIF3L1.
Phosphorylated by CK2 and PKD kinases. Belongs to the CSN2 family and contains one PCI domain.
Component of the CSN complex composed of COPS1–COPS8 subunits, interacting directly with COPS1, COPS4, COPS5, COPS6, and COPS7 (A or B isoforms). Interacts with CUL1, CUL2, thyroid receptor ligand-binding domain (independent of thyroid hormone), IRF8/ICSBP1, and nuclear receptors NR2F1 and NR0B1.
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