ELK Biotechnology DDR1 rabbit pAb
DDR1 rabbit pAb는 인간 DDR1 유래 합성 펩타이드로 제작된 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 세포막 단백질 DDR1 검출에 사용되며, 인간·마우스·랫트 시료에 반응합니다. -20°C 보관 시 1년 안정적입니다.
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DDR1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DDR1 (AA range: 749-798) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kD |
| Gene ID (Human) | 780 |
| Human Swiss-Prot No. | Q08345 |
| Cellular Localization | Isoform 1: Cell membrane (Single-pass type I membrane protein) Isoform 2: Cell membrane (Single-pass type I membrane protein) Isoform 3: Secreted Isoform 4: Cell membrane (Single-pass type I membrane protein) |
| Species Reactivity | Human; Mouse; Rat |
Background
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation, and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain and are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. It has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Feb 2011)
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