ELK Biotechnology Caspase-1 (phospho Ser376) rabbit pAb
Caspase-1 (phospho Ser376) rabbit polyclonal antibody for detection of phosphorylated Caspase-1. Applicable to WB, IHC, IF, ELISA. Recognizes human, mouse, and rat proteins. High specificity and stability with long-term storage at -20°C.
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Caspase-1 (phospho Ser376) Rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product Name | Caspase-1 (phospho Ser376) rabbit pAb |
| Alternative Names | CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase-1 around the phosphorylation site of Ser376 (AA range: 342–391) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| Gene ID (Human) | 834 |
| Human Swiss-Prot No. | P29466 |
| Cellular Localization | Cytoplasm, Cell membrane |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a protein that belongs to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a crucial role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits (large and small) that dimerize to form the active enzyme.
Caspase-1 was identified by its ability to cleave and activate the inactive precursor of interleukin-1, a cytokine involved in inflammation, septic shock, and wound healing. It has been shown to induce apoptosis and may function in various developmental stages. Studies in mouse suggest a role in Huntington disease pathogenesis. Alternative splicing results in distinct isoforms.
[Provided by RefSeq, Mar 2012]
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