ELK Biotechnology WAVE1 (phospho Tyr125) rabbit pAb
WAVE1 (phospho Tyr125) rabbit pAb는 인간, 마우스, 랫트 시료에서 인산화된 WAVE1 단백질을 검출하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적합하며 세포골격 및 세포접착 관련 연구에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
WAVE1 (phospho Tyr125) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | WASF1; KIAA0269; SCAR1; WAVE1; Wiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; Protein WAVE-1; Verprolin homology domain-containing protein 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human WAVE1 around the phosphorylation site of Tyr125 (AA range: 91-140) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kDa |
| Gene ID (Human) | 8936 |
| Human Swiss-Prot No. | Q92558 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, cytoskeleton; Cell junction, synapse; Cell junction, focal adhesion.
Dot-like pattern in cytoplasm, concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097).
Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2 (PubMed:18559503).
In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through association with TMEM108 (By similarity).
배경 (Background)
The WAVE1 protein, a member of the Wiskott-Aldrich syndrome protein (WASP) family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling.
It associates with the actin nucleation core Arp2/3 complex to enhance actin polymerization in vitro.
Wiskott-Aldrich syndrome is an immune system disorder likely caused by defects in actin cytoskeleton regulation.
Multiple alternatively spliced transcript variants encoding the same protein have been identified (RefSeq, Jul 2008).
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