Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (53-6.7), PE

Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (53-6.7), PE

Applications

• Flow Cytometry (Flow): Tested at 2 µg/mL
  View 7 publications
• Miscellaneous PubMed (Misc): —
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Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• APC
• FITC
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of murine CD8α (32–34 kDa; alpha chain of the CD8 antigen).

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a key role in signal transduction and T cell differentiation and activation.
CD8 is expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
CD8α is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers.
Upon ligation with MHC-I/peptide complexes, CD8 recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are essential for pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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