Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (53-6.7), PE
마우스 CD8α 항체로, PE 형광단백질로 결합된 Rat IgG2a 모노클론 항체입니다. Flow Cytometry에 최적화되어 있으며, 565/576 nm의 Excitation/Emission 특성을 가집니다. PBS 완충액에 보관하며, 4°C 암소 저장이 권장됩니다.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (53-6.7), PE
Applications
- Flow Cytometry (Flow): Tested at 2 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 53-6.7 |
| Immunogen | Mouse spleen cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM Sodium Azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156191 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of murine CD8α (32–34 kDa; alpha chain of the CD8 antigen).
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a key role in signal transduction and T cell differentiation and activation.
CD8 is expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
CD8α is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers.
Upon ligation with MHC-I/peptide complexes, CD8 recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are essential for pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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