ELK Biotechnology SF3B1 (phospho-Thr313) rabbit pAb
SF3B1 (phospho-Thr313) rabbit polyclonal antibody는 human 및 mouse 시료에서 SF3B1 단백질의 인산화 형태를 검출합니다. WB 및 IHC에 적합하며, 핵 내 localization 연구에 활용됩니다. 고순도 IgG로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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- ES13144-xxxxx (2개 옵션)
- 판매단위
- pk
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SF3B1 (phospho-Thr313) rabbit pAb
제품 개요
SF3B1 (phospho-Thr313) rabbit polyclonal antibody는 Splicing factor 3B subunit 1의 Thr313 인산화 부위를 인식하는 항체입니다. 본 항체는 핵 내 스플라이싱 인자 복합체 연구에 유용하며, Western blot(WB) 및 Immunohistochemistry(IHC)에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SF3B1 (phospho-Thr313) rabbit pAb |
| Alternative Names | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit), SF3b155, Spliceosome-associated protein 155, SAP 155 |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized phospho peptide around human SF3B1 (Thr313) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 145 kD |
| GeneID (Human) | 23451 |
| Human Swiss-Prot No | O75533 |
| Cellular Localization | Nucleus, Nucleus speckle. During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm. |
| Species Reactivity | Human; Mouse |
Background
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron’s branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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