Thermo Fisher Scientific Caspase 10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 220-521 of human Caspase-10 (NP_1167592) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Caspase 10,uniProtId:Q92851-1,ncbiNodeId:9606,antigenRange:220-521,antigenLength:521,antigenImageFileName:PA5-120032_Caspase_10_Q92851-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120032_Caspase_10_Q92851-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.38 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2913604

Product Specific Information

Positive test controls include: Jurkat, NIH/3T3.

Immunogen sequence: VKTFLEALPQ ESWQNKHAGS NGNRATNGAP SLVSRGMQGA SANTLNSETS TKRAAVYRMN RNHRGLCVIV NNHSFTSLKD RQGTHKDAEI LSHVFQWLGF TVHIHNNVTK VEMEMVLQKQ KCNPAHADGD CFVFCILTHG RFGAVYSSDE ALIPIREIMS HFTALQCPRL AEKPKLFFIQ ACQGEEIQPS VSIEADALNP EQAPTSLQDS IPAEADFLLG LATVPGYVSF RHVEEGSWYI QSLCNHLKKL VPRHEDILSI LTAVNDDVSR RVDKQGTKKQ MPQPAFTLRK KLVFPVPLDA LS

Target Information

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.