Thermo Fisher Scientific GP130 Monoclonal Antibody (125623)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 8–25 µg/mL
• Publications: [References not provided]

Flow Cytometry (Flow)

• Tested Dilution: 0.25 µg per million cells
• Publications: [References not provided]

Product Specifications

Product Specific Information

• No cross-reactivity with recombinant human gp130 observed in Western blots.
• Reconstitute at 0.5 mg/mL in sterile PBS.
• Endotoxin level <0.10 EU per 1 µg of antibody (LAL method).

Target Information

The GP130 protein acts as a signal transducer shared by multiple cytokines such as IL6, CNTF, LIF, and OSM. It functions as part of the cytokine receptor complex, with activation dependent on cytokine-receptor binding. Viral IL6 (vIL6) from Kaposi sarcoma-associated herpesvirus can directly activate GP130 without IL6R. Mouse knockout studies indicate its critical role in regulating myocyte apoptosis. Multiple alternatively spliced isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.