Thermo Fisher Scientific GP130 Monoclonal Antibody (125623)
Thermo Fisher Scientific의 GP130 단일클론 항체(125623)는 인간 및 마우스 반응성을 가지며, 단백질 A/G 정제된 비결합 항체입니다. ICC/IF 및 유세포분석에 적합하며, 재구성 후 0.5 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 8–25 µg/mL
- Publications: [References not provided]
Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg per million cells
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 125623 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse gp130 (Gln23–Glu617, predicted) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608198 |
Product Specific Information
- No cross-reactivity with recombinant human gp130 observed in Western blots.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level <0.10 EU per 1 µg of antibody (LAL method).
Target Information
The GP130 protein acts as a signal transducer shared by multiple cytokines such as IL6, CNTF, LIF, and OSM. It functions as part of the cytokine receptor complex, with activation dependent on cytokine-receptor binding. Viral IL6 (vIL6) from Kaposi sarcoma-associated herpesvirus can directly activate GP130 without IL6R. Mouse knockout studies indicate its critical role in regulating myocyte apoptosis. Multiple alternatively spliced isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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