Thermo Fisher Scientific CRHBP Polyclonal Antibody
CRHBP 단백질을 인식하는 Thermo Fisher Scientific의 산염기성 다클론 항체. Western blot과 IHC에 적합하며, 마우스 시료에 반응. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 동결 건조 형태로 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (IHC) | 5–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse CRHBP (Tyr25–Leu322) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607416 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 70% cross-reactivity with recombinant human CRHBP is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus.
CRH is a 41 amino acid peptide derived by enzymatic cleavage from a 191 amino acid preprohormone. It is produced not only in the hypothalamus but also in peripheral tissues such as T lymphocytes and is highly expressed in human placenta.
Glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta, contrasting with glucocorticoid suppression of CRH expression in the hypothalamus.
The gene encoding CRH maps to human chromosome 8q13. Human plasma contains a CRH-binding protein (CRH-BP, also designated CRF-BP) that inactivates CRH and may prevent inappropriate pituitary-adrenal stimulation during pregnancy. The gene encoding CRF-BP maps to human chromosome 5q11.2–q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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