Thermo Fisher Scientific NUMB Monoclonal Antibody (OTI4H2), TrueMAB
Human NUMB 단백질(aa 1–365)에 특이적인 Mouse IgG1 단클론 항체로, Western blot에 최적화된 TrueMAB 제품. Lyophilized 형태로 제공되며, PBS/trehalose buffer에 보관. 신경세포 분화 및 endocytosis 연구에 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–365 of human NUMB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls neuronal progenitor cell differentiation.
NUMB functions in clathrin-dependent endocytosis via binding to the AP-2 complex and is expressed in postmitotic neurons, playing a role in axonal growth.
Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domains exhibit extensive neurite outgrowth, which can be blocked by voltage-gated Ca²⁺ channel inhibitors or Ca²⁺ chelators.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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