Thermo Fisher Scientific NUMB Monoclonal Antibody (OTI4H2), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

Protein NUMB homolog is an evolutionarily conserved protein that controls neuronal progenitor cell differentiation.
NUMB functions in clathrin-dependent endocytosis via binding to the AP-2 complex and is expressed in postmitotic neurons, playing a role in axonal growth.
Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domains exhibit extensive neurite outgrowth, which can be blocked by voltage-gated Ca²⁺ channel inhibitors or Ca²⁺ chelators.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.