Thermo Fisher Scientific ALX3 Polyclonal Antibody
ALX3 단백질을 검출하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 36 kDa 내인성 단백질을 검출합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 171–220 of human ALX3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553385 |
Product Specific Information
- Detects endogenous ALX3 protein at a molecular weight of approximately 36 kDa.
- Purity is greater than 95% by SDS-PAGE.
Target Information
Aristaless-related genes are a group of paired-related homeobox genes involved in vertebrate embryogenesis regulation. The homeodomain transcription factor Aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, mainly in neural crest-derived mesenchyme and lateral plate mesoderm.
Expression analysis shows predominant ALX3 expression in brain tissue for both human and mouse. The Alx3 gene maps to chromosome 1p23–p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma, potentially repressing ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression.
Alx3 knockout mice show no distinct phenotype compared to wild-type, but Alx3/Alx4 double mutants exhibit severe craniofacial abnormalities, including cleft nasal regions and malformation of neural crest-derived skull structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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