Thermo Fisher Scientific TTI1 Polyclonal Antibody
TTI1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot 및 Immunoprecipitation에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. DNA 손상 반응 연구 및 PIKK 단백질 안정화 연구에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human Tel2 Interacting Protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
TTI1 is a regulator of the DNA damage response (DDR). It is part of the TTT complex, which stabilizes protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family. The TTT complex contributes to cellular resistance against DNA damage stresses such as ionizing radiation (IR), ultraviolet (UV), and mitomycin C (MMC).
Together with HSP90, it may assist in the proper folding of newly synthesized PIKKs. TTI1 promotes assembly, stabilizes, and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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