Thermo Fisher Scientific MMP2/Collagenase Type IV A (Tumor Metastasis Marker) Monoclonal Antibody (MMP2/4586)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a common activation mechanism and a conserved amino acid sequence in the metal-binding active site, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs).
MMPs and TIMPs play significant roles in regulating angiogenesis and tissue remodeling.

MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. The MMP family includes at least eighteen secreted and membrane-bound zinc endopeptidases that collectively degrade various extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins.

Mutations in the MMP2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.