Thermo Fisher Scientific TIMD2 Chimeric Recombinant Rabbit Monoclonal Antibody (RMT2-14)
마우스 TIM-2 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF, Flow, Functional, Inhibition Assay에 사용 가능. HEK293 세포에서 발현된 IgG 람다형 항체이며, Protein A로 정제된 액상 형태. Th2 세포 활성화 및 아토피 질환 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Functional Assay | Assay-dependent |
| Inhibition Assays | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, lambda |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RMT2-14 |
| Immunogen | This antibody was raised by immunising Sprague Dawley rats with TIM-2-Ig consisting of the extracellular domain (aa 1–230 of mouse TIM-2) and the Fc portion of mouse IgG2a, emulsified in complete Freund’s adjuvant and then fusing lymph node cells from the immunized rats with P3U1 myeloma cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074610 |
Product Specific Information
This antibody is specific for murine TIM-2, a transmembrane protein expressed on activated T cells and preferentially on differentiated Th2 cells. Blocking TIM-2/TIM-2 ligand interaction results in T cell hyperproliferation and Th2 cytokine production. TIM-2 plays a critical role in the development of atopic disease and other Th2-biased immune responses.
Target Information
TIM-2 (T-cell immunoglobulin mucin 2) is a transmembrane glycoprotein and member of the immunoglobulin superfamily. It is expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells while down-regulated in Th1 cells. TIM-2 acts as a negative regulator of Th2 cells and is implicated in the development of atopic disease and other Th2-biased immune responses. It also serves as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, involved in axonal guidance and enhancement of T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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