Thermo Fisher Scientific ATF5 Polyclonal Antibody
ATF5 단백질을 표적하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 반응성을 보입니다. Western blot에 최적화되어 있으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 세포 생존 및 분화 관련 연구에 적합합니다.
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Thermo Fisher Scientific ATF5 Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EVYKARSQRTRSC) corresponding to the C-terminus amino acids of ATF5 (aa 270–282) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_11004131 |
Product Specific Information
- Predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
ATF5 is a protein coding gene and transcription factor that can stimulate or repress gene transcription through binding of various DNA regulatory elements such as cAMP response element (CRE), ATF5-specific response element (ARE), and amino acid response element (AARE). It plays critical roles in cell survival, proliferation, and differentiation, particularly in cerebral cortical neuroprogenitor cells.
ATF5 is involved in the regulation of cerebral cortex formation, olfactory sensory neuron survival, and osteogenic differentiation. It promotes cell proliferation and survival by inducing EGR1 expression synergistically with ELK1 and regulates anti-apoptotic pathways via BCL2 transcriptional activation.
Additionally, ATF5 cooperates with NR1I3/CAR for transcriptional activation of CYP2B6 in liver and acts as a cofactor of CEBPB to promote adipocyte differentiation. It also regulates centrosome dynamics in a centriole-age-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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