Thermo Fisher Scientific Phospho-TRPV1 (Ser502) Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

Phospho-TRPV1 (Ser502) Polyclonal Antibody detects endogenous levels of TRPV1 only when phosphorylated at Ser502.

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. It is permeable to calcium, magnesium, and monovalent cations of sodium and potassium.
Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
TRPV1 mediates proton influx and may be involved in intracellular acidosis in nociceptive neurons. Its expression appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in the 5′ UTR sequence have been described.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.