Thermo Fisher Scientific TRIB2 Polyclonal Antibody
Human TRIB2 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체이며, PBS와 40% 글리세롤 버퍼에 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA551555
- 판매단위
- pk
카탈로그
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TRIB2. Recombinant protein control fragment (Product #RP-95138). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648907 |
Product Specific Information
Immunogen sequence:
TIARYGRSRN KTQDFEELSS IRSAEPSQSF SPNLGSPSPP ETPNLSHCVS CIGKYLLLEP LEGDHVFRAV HLHSGEELVC KVFDISCYQE SLAPCFCLSA HSNINQITEI ILGETKAYVF FERSYGDMHS FVRTCKKLRE
Sequence identity to orthologs:
- Mouse: 99%
- Rat: 41%
Target Information
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases but lacks the active site lysine and likely lacks catalytic function. Tribbles proteins interact and modulate signal transduction pathways in various physiological and pathological processes.
TRIB2 induces apoptosis mainly in hematopoietic cells and is up-regulated by inflammatory stimuli in myeloid (THP-1) cells. It also acts as an oncogene by inactivating the transcription factor C/EBPalpha, contributing to acute myelogenous leukemia. Alternatively spliced transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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