Thermo Fisher Scientific PC4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PC4. Recombinant protein control fragment (Product #RP-95157). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PC4,uniProtId:P53999-1,ncbiNodeId:9606,antigenRange:8-117,antigenLength:127,antigenImageFileName:PA5-51557_PC4_P53999-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51557_PC4_P53999-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.02 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645240

Product Specific Information

Immunogen sequence: VSSSSSGSDS DSEVDKKLKR KKQVAPEKPV KKQKTGETSR ALSSSKQSSS SRDDNMFQIG KMRYVSVRDF KGKVLIDIRE YWMDPEGEMK PGRKGISLNP EQWSQLKEQI

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

Target Information

PC4 (activated RNA polymerase II transcription cofactor 4) is a transcriptional coactivator, possessing the ability to suppress promoter-driven as well as nonspecific transcription via its DNA binding activity. The repressive activity of PC4 on promoter-driven transcription is alleviated by transcription factor TFIIH. TFIIH protects promoters from PC4-mediated repression by relieving the topological constraint imposed by PC4 through the ERCC3 helicase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.