Thermo Fisher Scientific Human HGF Recombinant Protein, PeproTech

Applications

ELISA (ELISA)

• Tested Dilution: -
• Publications: View 1 publication

Functional Assay (Functional)

• Assay-dependent
• Publications: View publication

In vitro Assay (IV)

• Tested Dilution: -
• Publications: View 42 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: -
• Publications: View 10 publications

Product Specifications

Product Specific Information

Recombinant Human HGF, sourced from HEK293 cells, is a 79.4 kDa polypeptide consisting of 695 amino acid residues. Due to glycosylation, Recombinant Human HGF migrates with an apparent molecular mass of approximately 68–85 kDa by SDS-PAGE under non-reducing conditions.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.

Target Information

Hepatocyte Growth Factor (HGF) regulates cell growth, motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the c-Met receptor. It is secreted by mesenchymal cells and functions as a multifunctional cytokine primarily on epithelial cells.
HGF stimulates mitogenesis, cell motility, and matrix invasion, playing a key role in angiogenesis, tumorigenesis, and tissue regeneration. It is secreted as an inactive single-chain precursor, which is cleaved by serine proteases into a 69-kDa alpha-chain and a 34-kDa beta-chain. The active heterodimeric form is stabilized by a disulfide bond between the two chains.
HGF belongs to the plasminogen subfamily of S1 peptidases but lacks protease activity. Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.