Thermo Fisher Scientific NTSR2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NTSR2, validated for IHC (paraffin). Recognizes neurotensin receptor 2 involved in G protein-coupled signaling. High species identity across primates. Supplied unconjugated, 1 mg/mL in PBS with sodium azide. S...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4–7 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 3rd extracellular domain of human NTSR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551389 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%), Marmoset (89%).
Target Information
The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.
Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands described for the neurotensin NT1 receptor.
Unlike NT1 receptor, this gene recognizes levocabastine—a histamine H1 receptor antagonist—with high affinity, previously shown to compete with neurotensin for low-affinity binding sites in brain.
These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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