Thermo Fisher Scientific NRG1 Polyclonal Antibody
NRG1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 비인간 영장류에 반응합니다. IHC(P) 실험에 적합하며, 고순도의 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from internal region of human NRG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551382 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey, Marmoset (100%), Gibbon (94%), Mouse, Rat, Hamster, Elephant, Bat, Horse, Pig, Platypus (82%).
Target Information
Neuregulin 1 (NRG1) is a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase tyrosine phosphorylation. Multiple isoforms are produced via alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).
These isoforms differ in structure and tissue-specific expression:
- HRG isoforms contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains.
- GGF and GGF2 isoforms include kringle-like, Ig, and EGF-like domains.
- SMDF isoform shares only the EGF-like domain.
All NRG1 isoforms interact with ERBB family receptors, inducing growth and differentiation of epithelial, neuronal, glial, and other cell types.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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