Thermo Fisher Scientific NRG1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Monkey, Marmoset (100%), Gibbon (94%), Mouse, Rat, Hamster, Elephant, Bat, Horse, Pig, Platypus (82%).

Target Information

Neuregulin 1 (NRG1) is a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase tyrosine phosphorylation. Multiple isoforms are produced via alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).
These isoforms differ in structure and tissue-specific expression:

• HRG isoforms contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains.
• GGF and GGF2 isoforms include kringle-like, Ig, and EGF-like domains.
• SMDF isoform shares only the EGF-like domain.

All NRG1 isoforms interact with ERBB family receptors, inducing growth and differentiation of epithelial, neuronal, glial, and other cell types.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.