Thermo Fisher Scientific STAT5 alpha/beta Recombinant Rabbit Monoclonal Antibody (ARC1215)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1215

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 600-786 of human STAT5 (P42229) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:STAT5 alpha/beta,uniProtId:P42229-1,ncbiNodeId:9606,antigenRange:600-786,antigenLength:794,antigenImageFileName:MA5-35625_STAT5_alphabeta_P42229-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35625_STAT5_alphabeta_P42229-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:STAT5 alpha/beta,uniProtId:P51692-1,ncbiNodeId:9606,antigenRange:600-786,antigenLength:787,antigenImageFileName:MA5-35625_STAT5_alphabeta_P51692-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35625_STAT5_alphabeta_P51692-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849525

Product Specific Information

Immunogen sequence: KQQAHDLLIN KPDGTFLLRF SDSEIGGITI AWKFDSPERN LWNLKPFTTR DFSIRSLADR LGDLSYLIYV FPDRPKDEVF SKYYTPVLAK AVDGYVKPQI KQVVPEFVNA SADAGGSSAT YMDQAPSPAV CPQAPYNMYP QNPDHVLDQD GEFDLDETMD VARHVEELLR RPMDSLDSRL SPPAGLF

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.