Thermo Fisher Scientific CD51 (Integrin alpha V) Monoclonal Antibody (RMV-7)
마우스 CD51(Integrin αV)을 인식하는 단클론 항체로, Flow Cytometry, Immunoprecipitation, Functional Assay에 적합합니다. Rat IgG1 아이소타입이며 Protein G로 정제되었습니다. 비보존제 PBS 용액 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RMV-7 |
| Immunogen | Cultured LAK cells from Balb/c mice (target: Integrin alpha V (CD51), UniProt ID: P43406-1, antigen range: 1–1044) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745151 |
Product Specific Information
This antibody recognizes murine CD51, approximately a 140 kDa alpha subunit of the vitronectin receptor, also known as the integrin alpha V chain. CD51 can form heterodimers at the cell surface with various beta integrins including CD29 and CD61.
Target Information
The ITAGV gene encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, combining with multiple integrin beta chains to form different integrins.
Among the known associating beta chains (β1, β3, β5, β6, and β8; ITGB1, ITGB3, ITGB5, ITGB6, ITGB8), each interacts with extracellular matrix ligands. The αVβ3 integrin, also known as the Vitronectin Receptor (VNR), is one of the most studied. In addition to adhesion, many integrins facilitate signal transduction.
The ITGB3 protein product forms the integrin beta chain β3, which pairs with the alpha IIb chain in platelets. Integrins participate in both cell adhesion and cell-surface–mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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