Thermo Fisher Scientific Lysine Acetylated Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

• Store at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Centrifuge product if not completely clear after standing at room temperature.
• This product is stable for several weeks at 4°C as an undiluted liquid (dilute only prior to immediate use).

Target Information

In the nucleus, DNA is tightly packed into nucleosomes generating an environment that is highly repressive toward DNA processes such as transcription.
Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression.
The acetylation of non-histone proteins such as transcription factors, as well as histones, appears to be involved in this process.
Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains.
The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain.
Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.