Thermo Fisher Scientific E-Cadherin/ CD324 (Intercellular Junction Marker) Monoclonal Antibody (SPM381)
E-Cadherin/CD324 단클론 항체로 세포 간 접합 마커 검출에 적합. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. 인간 및 마우스 반응성, Protein A/G 정제, 액상 형태로 4°C 보관. 연구용으로만 사용.
- 카탈로그번호
- 999-MSM5X-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific E-Cadherin/ CD324 (Intercellular Junction Marker) Monoclonal Antibody (SPM381)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Immunomicroscopy (IM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM381 |
| Immunogen | Recombinant human E-Cadherin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Mutations in the CDH1 gene encoding E-Cadherin are associated with various cancers, including gastric, breast, colorectal, thyroid, and ovarian. Loss of E-Cadherin function contributes to cancer progression through increased proliferation, invasion, and metastasis. The ectodomain mediates bacterial adhesion, while the cytoplasmic domain is essential for internalization. E-Cadherin plays a crucial role in maintaining tissue architecture and integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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