Thermo Fisher Scientific Arginase 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Specific for endogenous levels of the ~35–38 kDa arginase I protein.

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are important for cell proliferation and detoxification of ammonia derived from protein degradation. By degrading arginine, Arginase 1 deprives nitric oxide synthase of its substrate and down-regulates nitric oxide production.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 expression is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 may also be expressed in tumor-infiltrating myeloid cells and is typically found in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.