Thermo Fisher Scientific GABA(A) alpha 1 Receptor (extracellular) Polyclonal Antibody, Atto 488

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitution: 50 µL double distilled water (DDW), depending on sample size
• Ships as lyophilized powder at room temperature
• Store at -20°C upon arrival
• Reconstituted solution stable at 4°C for up to 1 week
• For long-term storage, aliquot and store at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, inducing membrane hyperpolarization by opening Cl⁻ channels associated with the GABAA receptor (GABAA-R).
GABAA-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are involved in diseases such as epilepsy, anxiety, depression, and substance abuse.
The receptor is a multimeric complex composed of multiple subunits (alpha, beta, gamma, etc.), including splice variants.
Functional GABAA-Rs can be expressed by coexpression of alpha and beta subunits, while the gamma subunit is required for benzodiazepine modulation.
Phosphorylation of beta subunits has been shown to modulate receptor function.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.