Thermo Fisher Scientific GABA(A) alpha 1 Receptor (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution:

• Reconstitute with 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
• Ships lyophilized at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C (protected from light) for up to 1 week.
• For long-term storage, aliquot and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, inducing membrane hyperpolarization through Cl⁻ channel opening associated with the GABAA receptor (GABAA-R) subtype.
GABAA-Rs are key therapeutic targets for sedatives, anxiolytics, and hypnotics, and are implicated in disorders such as epilepsy, anxiety, depression, and substance abuse.
The GABAA-R is a multimeric subunit complex consisting of multiple alpha, beta, and gamma subunits, including splice variants.
Expression of alpha and beta subunits produces functional GABAA-Rs sensitive to GABA, while coexpression with a gamma subunit enables benzodiazepine modulation.
Different alpha subunits may mediate distinct benzodiazepine effects, and phosphorylation of beta subunits modulates receptor function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.